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Home - Products - Angiogenesis - Bcl-2 - Chelerythrine chloride

Chelerythrine chloride

CAS No. 3895-92-9

Chelerythrine chloride ( Broussonpapyrine chloride; NSC 646662 )

Catalog No. M14342 CAS No. 3895-92-9

Chelerythrine chloride is a potent, cell-permeable inhibitor of PKC (IC50=66 nM) and p38 MAPK.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Chelerythrine chloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Chelerythrine chloride is a potent, cell-permeable inhibitor of PKC (IC50=66 nM) and p38 MAPK.
  • Description
    Chelerythrine chloride is a potent, cell-permeable inhibitor of PKC (IC50=66 nM) and p38 MAPK, also inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 uM and displaces Bax from Bcl-XL; inhibits LPS-induced TNF-α level and NO production in LPS-induced murine peritoneal macrophages through selective inhibition of p38 MAPK and ERK1/2 activation; triggers apoptosis via direct action on mitochondria.
  • Synonyms
    Broussonpapyrine chloride; NSC 646662
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    PKC
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    3895-92-9
  • Formula Weight
    383.82
  • Molecular Formula
    C21H18ClNO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 3.9 mg/mL
  • SMILES
    C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-]
  • Chemical Name
    1,2-Dimethoxy-12-methyl[1,3]benzodi oxolo[5,6-c]phenanthridinium chloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chan SL, et al. J Biol Chem. 2003 Jun 6;278(23):20453-6.
2. Li W, et al. Inflammation. 2012 Dec;35(6):1814-24.
3. Wan KF, et al. J Biol Chem. 2008 Mar 28;283(13):8423-33.
4. Zhang YH, et al. J Mol Biol. 2006 Dec 1;364(3):536-49.
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